Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0003085 | negative regulation of systemic arterial blood pressure |
| Biological Process | GO:0071805 | potassium ion transmembrane transport |
| Biological Process | GO:0006813 | potassium ion transport |
| Biological Process | GO:0034765 | regulation of monoatomic ion transmembrane transport |
| Biological Process | GO:0060075 | regulation of resting membrane potential |
| Biological Process | GO:0030322 | stabilization of membrane potential |
| Molecular Function | GO:0005242 | inward rectifier potassium channel activity |
| Molecular Function | GO:0022841 | potassium ion leak channel activity |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0008076 | voltage-gated potassium channel complex |
| InterPro
|
InterPro name |
|---|---|
| IPR003092 | Two pore domain potassium channel, TASK family |
| IPR003280 | Two pore domain potassium channel |
| IPR005408 | Two pore domain potassium channel, TWIK family |
| IPR005409 | Two pore domain potassium channel, TWIK-2 |
| IPR013099 | Potassium channel domain |
| Pfam
|
Pfam name |
|---|---|
| PF07885 | Ion channel |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1299308 | Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) | Leaf | R-HSA-112316 | Neuronal System |
| R-HSA-5576886 | Phase 4 - resting membrane potential | Leaf | R-HSA-397014 | Muscle contraction |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Membrane | ECO:0000305 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | adipocytes | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | High | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | High | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | High | Approved |
| liver | hepatocytes | Low | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| placenta | trophoblastic cells | High | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | High | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | chondrocytes | Medium | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in red pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|