MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.1.150	Transferases; Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor; 1-phosphatidylinositol-3-phosphate 5-kinase
2.7.11.1	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; non-specific serine/threonine protein kinase

Structure

PDB	Resolution (Å)	PDB name
7K2V	6.6	PIKfyve/Fig4/Vac14 complex centered on PIKfyve - map2

GO term

GO ontology	GO term	GO description
Biological Process	GO:1903100	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0032438	melanosome organization
Biological Process	GO:0032288	myelin assembly
Biological Process	GO:0030593	neutrophil chemotaxis
Biological Process	GO:0036289	peptidyl-serine autophosphorylation
Biological Process	GO:0090382	phagosome maturation
Biological Process	GO:0090385	phagosome-lysosome fusion
Biological Process	GO:1904562	phosphatidylinositol 5-phosphate metabolic process
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process
Biological Process	GO:0034504	protein localization to nucleus
Biological Process	GO:0006612	protein targeting to membrane
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell
Biological Process	GO:2000785	regulation of autophagosome assembly
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process
Biological Process	GO:0042147	retrograde transport, endosome to Golgi
Molecular Function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity
Molecular Function	GO:0052810	1-phosphatidylinositol-5-kinase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0043813	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0031902	late endosome membrane
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0030670	phagocytic vesicle membrane
Cellular Component	GO:0012506	vesicle membrane

InterPro / Pfam

InterPro	InterPro name
IPR000306	FYVE zinc finger
IPR000591	DEP domain
IPR002423	Chaperonin Cpn60/GroEL/TCP-1 family
IPR002498	Phosphatidylinositol-4-phosphate 5-kinase, core
IPR011011	Zinc finger, FYVE/PHD-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR017455	Zinc finger, FYVE-related
IPR027409	GroEL-like apical domain superfamily
IPR027410	TCP-1-like chaperonin intermediate domain superfamily
IPR027484	Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036390	Winged helix DNA-binding domain superfamily
IPR037378	PIKfyve, DEP domain
IPR043548	1-phosphatidylinositol-3phosphate-5-kinase
IPR044769	1-phosphatidylinositol-3-phosphate 5-kinase, PIPK catalytic domain

Pfam	Pfam name
PF00118	TCP-1/cpn60 chaperonin family
PF00610	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PF01363	FYVE zinc finger
PF01504	Phosphatidylinositol-4-phosphate 5-Kinase

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	Leaf	R-HSA-1430728	Metabolism
R-HSA-1660516	Synthesis of PIPs at the early endosome membrane	Leaf	R-HSA-1430728	Metabolism
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane	Leaf	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Cytoplasmic vesicle, phagosome membrane	ECO:0000269	PubMed:30612035
Early endosome membrane	ECO:0000269	PubMed:30612035
Endosome membrane	ECO:0000269	PubMed:11706043
Endosome membrane	ECO:0000269	PubMed:17556371
Late endosome membrane	ECO:0000269	PubMed:11706043

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000613	Photophobia
HP:0007962	Speckled corneal dystrophy

Summary of Q9Y2I7

Gene: PIKFYVE, KIAA0981, PIP5K3
Protein: 1-phosphatidylinositol 3-phosphate 5-kinase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q9Y2I7

Gene: PIKFYVE, KIAA0981, PIP5K3 Protein: 1-phosphatidylinositol 3-phosphate 5-kinase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: PIKFYVE, KIAA0981, PIP5K3
Protein: 1-phosphatidylinositol 3-phosphate 5-kinase