MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q9Y2L1

Gene: DIS3, KIAA1008, RRP44
Protein: Exosome complex exonuclease RRP44

Protein family
Protein sequence
Protein function

Catalytic activity

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EC number	EC number description
3.1.13.-	Hydrolases; Acting on ester bonds; Exoribonucleases producing 5'-phosphomonoesters;
3.1.26.-	Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters;

Showing 1 to 2 of 2 entries

Publications

Structure

GO term

InterPro / Pfam

Reactome

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Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-380994	ATF4 activates genes in response to endoplasmic reticulum stress	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-429958	mRNA decay by 3' to 5' exoribonuclease	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	Leaf	R-HSA-8953854	Metabolism of RNA

Showing 1 to 6 of 6 entries

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

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Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Approved
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Low	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Low	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Medium	Approved
bronchus	respiratory epithelial cells	High	Approved
caudate	glial cells	Medium	Approved

Showing 1 to 10 of 78 entries

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Disease