Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.13.-
Hydrolases;
Acting on ester bonds;
Exoribonucleases producing 5'-phosphomonoesters;
3.1.26.-
Hydrolases;
Acting on ester bonds;
Endoribonucleases producing 5'-phosphomonoesters;
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0071034 | CUT catabolic process |
| Biological Process | GO:0006401 | RNA catabolic process |
| Biological Process | GO:0006396 | RNA processing |
| Biological Process | GO:0043928 | exonucleolytic catabolism of deadenylated mRNA |
| Biological Process | GO:0016075 | rRNA catabolic process |
| Biological Process | GO:0006364 | rRNA processing |
| Molecular Function | GO:0000175 | 3'-5'-RNA exonuclease activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0004519 | endonuclease activity |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Cellular Component | GO:0000177 | cytoplasmic exosome (RNase complex) |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000178 | exosome (RNase complex) |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0000176 | nuclear exosome (RNase complex) |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR001900 | Ribonuclease II/R |
| IPR002716 | PIN domain |
| IPR012340 | Nucleic acid-binding, OB-fold |
| IPR022966 | Ribonuclease II/R, conserved site |
| IPR029060 | PIN-like domain superfamily |
| IPR033770 | Exosome complex exonuclease RRP44, S1 domain |
| IPR033771 | Rrp44-like cold shock domain |
| IPR041505 | Dis3-like cold-shock domain 2 |
| Pfam
|
Pfam name |
|---|---|
| PF00773 | RNB domain |
| PF13638 | PIN domain |
| PF17215 | S1 domain |
| PF17216 | Rrp44-like cold shock domain |
| PF17849 | Dis3-like cold-shock domain 2 (CSD2) |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Leaf | R-HSA-8953854 | Metabolism of RNA |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:20531386 |
| Nucleus | ECO:0000269 | PubMed:20531386 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:12429849 |
| Nucleus, nucleoplasm | ECO:0000269 | PubMed:20531389 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | adipocytes | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | High | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Low | Approved |
| hippocampus | glial cells | Medium | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Low | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | High | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | High | Approved |
| skin 1 | melanocytes | High | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| soft tissue 1 | chondrocytes | Medium | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | Low | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | High | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| plasma cell myeloma | MONDO:0009693 | C90 | chapter2, Neoplasms | OMIM:254500 | Orphanet:29073 |
| plasma cell myeloma | MONDO:0009693 | C90 | chapter2, Neoplasms | OMIM:254500 | Orphanet:314701 |
| plasma cell myeloma | MONDO:0009693 | C90 | chapter2, Neoplasms | OMIM:254500 | Orphanet:85443 |
| al amyloidosis | MONDO:0019438 | E85 | chapter4, Endocrine, nutritional and metabolic diseases | Orphanet:85443 |