MultifacetedProtDB - Bologna Biocomputing Group

Catalytic activity

EC number	EC number description
6.2.1.-	Ligases; Forming carbon-sulfur bonds; Acid-thiol ligases;
6.2.1.15	Ligases; Forming carbon-sulfur bonds; Acid-thiol ligases; arachidonate—CoA ligase
6.2.1.3	Ligases; Forming carbon-sulfur bonds; Acid-thiol ligases; long-chain-fatty-acid—CoA ligase

Publications

GO ontology	GO term	GO description
Biological Process	GO:0015909	long-chain fatty acid transport
Biological Process	GO:0000038	very long-chain fatty acid metabolic process
Molecular Function	GO:0047676	arachidonate-CoA ligase activity
Molecular Function	GO:0015245	fatty acid transmembrane transporter activity
Molecular Function	GO:0005324	long-chain fatty acid transporter activity
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity
Molecular Function	GO:0000166	nucleotide binding
Molecular Function	GO:1901480	oleate transmembrane transporter activity
Molecular Function	GO:0031957	very long-chain fatty acid-CoA ligase activity
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0042383	sarcolemma

InterPro	InterPro name
IPR000873	AMP-dependent synthetase/ligase domain
IPR020845	AMP-binding, conserved site
IPR025110	AMP-binding enzyme, C-terminal domain
IPR042099	ANL, N-terminal domain
IPR045851	AMP-binding enzyme, C-terminal domain superfamily

Pfam	Pfam name
PF00501	AMP-binding enzyme
PF13193	AMP-binding enzyme C-terminal domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-804914	Transport of fatty acids	Leaf	R-HSA-382551	Transport of small molecules

Location	ECO term	Pubmed
Cell membrane	ECO:0000250
Cell membrane, sarcolemma	ECO:0000305	PubMed:12556534

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Medium	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Low	Approved
cerebellum	Purkinje cells	Low	Approved
cerebellum	cells in granular layer	Low	Approved
cerebellum	cells in molecular layer	Low	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	glial cells	Low	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Low	Approved
cervix	squamous epithelial cells	Medium	Approved
endometrium 1	glandular cells	Low	Approved
endometrium 2	glandular cells	Low	Approved
esophagus	squamous epithelial cells	Medium	Approved
fallopian tube	ciliated cells (cell body)	High	Approved
fallopian tube	non-ciliated cells	High	Approved
heart muscle	cardiomyocytes	High	Approved
hippocampus	glial cells	Low	Approved
hippocampus	neuronal cells	Low	Approved
parathyroid gland	glandular cells	Low	Approved
placenta	trophoblastic cells	High	Approved
seminal vesicle	glandular cells	Medium	Approved
skeletal muscle	myocytes	Medium	Approved
smooth muscle	smooth muscle cells	Low	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	High	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	squamous epithelial cells	Low	Approved
vagina	squamous epithelial cells	Medium	Approved