MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1SYQ	2.42	Human vinculin head domain VH1, residues 1-258, in complex with human talin's vinculin binding site 1, residues 607-636
2MWN		Talin-F3 / RIAM N-terminal Peptide complex
4DJ9	2.25	Human vinculin head domain Vh1 (residues 1-258) in complex with the talin vinculin binding site 50 (VBS50, residues 2078-2099)
6R9T	6.2	Cryo-EM structure of autoinhibited human talin-1

GO term

GO ontology	GO term	GO description
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0007043	cell-cell junction assembly
Biological Process	GO:0007044	cell-substrate junction assembly
Biological Process	GO:0030866	cortical actin cytoskeleton organization
Biological Process	GO:0033622	integrin activation
Biological Process	GO:0007229	integrin-mediated signaling pathway
Biological Process	GO:0070527	platelet aggregation
Biological Process	GO:0051893	regulation of focal adhesion assembly
Molecular Function	GO:0030274	LIM domain binding
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0005178	integrin binding
Molecular Function	GO:0035091	phosphatidylinositol binding
Molecular Function	GO:0001786	phosphatidylserine binding
Molecular Function	GO:0005200	structural constituent of cytoskeleton
Molecular Function	GO:0017166	vinculin binding
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0001726	ruffle
Cellular Component	GO:0032587	ruffle membrane

InterPro / Pfam

InterPro	InterPro name
IPR000299	FERM domain
IPR002558	I/LWEQ domain
IPR011993	PH-like domain superfamily
IPR014352	FERM/acyl-CoA-binding protein superfamily
IPR015009	Vinculin-binding site-containing domain
IPR015224	Talin, central
IPR019747	FERM conserved site
IPR019748	FERM central domain
IPR019749	Band 4.1 domain
IPR029071	Ubiquitin-like domain superfamily
IPR032425	Talin, N-terminal F0 domain
IPR035963	FERM superfamily, second domain
IPR035964	I/LWEQ domain superfamily
IPR036476	Talin, central domain superfamily
IPR036723	Alpha-catenin/vinculin-like superfamily
IPR037438	Talin-1/2, rod-segment

Pfam	Pfam name
PF00373	FERM central domain
PF01608	I/LWEQ domain
PF08913	Vinculin Binding Site
PF09141	Talin, middle domain
PF16511	N-terminal or F0 domain of Talin-head FERM

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-114608	Platelet degranulation	Leaf	R-HSA-109582	Hemostasis
R-HSA-354192	Integrin signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	Leaf	R-HSA-109582	Hemostasis
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	Leaf	R-HSA-109582	Hemostasis
R-HSA-381038	XBP1(S) activates chaperone genes	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-445355	Smooth Muscle Contraction	Leaf	R-HSA-397014	Muscle contraction
R-HSA-5674135	MAP2K and MAPK activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	Leaf	R-HSA-1643685	Disease
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	Leaf	R-HSA-1643685	Disease
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	Leaf	R-HSA-1643685	Disease
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	Leaf	R-HSA-1643685	Disease
R-HSA-9649948	Signaling downstream of RAS mutants	Leaf	R-HSA-1643685	Disease
R-HSA-9656223	Signaling by RAF1 mutants	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cell junction, focal adhesion	ECO:0000250
Cell projection, ruffle membrane	ECO:0000250
Cell surface	ECO:0000250
Cytoplasm, cytoskeleton	ECO:0000250

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Supported
adrenal gland	glandular cells	Medium	Supported
appendix	glandular cells	Low	Supported
appendix	lymphoid tissue	High	Supported
bone marrow	hematopoietic cells	High	Supported
breast	adipocytes	Low	Supported
breast	glandular cells	High	Supported
breast	myoepithelial cells	Medium	Supported
bronchus	respiratory epithelial cells	High	Supported
caudate	glial cells	Medium	Supported
cerebellum	granular cells - cytoplasm/membrane	High	Supported
cerebellum	molecular layer cells - cytoplasm/membrane	High	Supported
cerebellum	processes in granular layer	High	Supported
cerebellum	synaptic glomeruli - core	Low	Supported
cerebellum	white matter cells - cytoplasm/membrane	High	Supported
cerebral cortex	endothelial cells	Medium	Supported
cerebral cortex	glial cells	Medium	Supported
cerebral cortex	neuropil	Low	Supported
cervix	glandular cells	Medium	Supported
cervix	squamous epithelial cells	Low	Supported
colon	endothelial cells	Medium	Supported
colon	glandular cells	Medium	Supported
colon	peripheral nerve/ganglion	Medium	Supported
duodenum	glandular cells	Medium	Supported
endometrium 1	cells in endometrial stroma	Low	Supported
endometrium 1	glandular cells	High	Supported
endometrium 2	cells in endometrial stroma	Low	Supported
endometrium 2	glandular cells	Low	Supported
epididymis	glandular cells	High	Supported
esophagus	squamous epithelial cells	Medium	Supported
fallopian tube	glandular cells	High	Supported
gallbladder	glandular cells	Medium	Supported
hippocampus	glial cells	Medium	Supported
kidney	cells in glomeruli	High	Supported
kidney	cells in tubules	Medium	Supported
liver	cholangiocytes	Medium	Supported
liver	hepatocytes	Low	Supported
lung	alveolar cells type I	Medium	Supported
lung	alveolar cells type II	Low	Supported
lung	endothelial cells	Medium	Supported
lung	macrophages	High	Supported
lymph node	germinal center cells	High	Supported
lymph node	non-germinal center cells	High	Supported
nasopharynx	respiratory epithelial cells	High	Supported
oral mucosa	squamous epithelial cells	Medium	Supported
ovary	ovarian stroma cells	Medium	Supported
pancreas	exocrine glandular cells	Medium	Supported
pancreas	pancreatic endocrine cells	Medium	Supported
parathyroid gland	glandular cells	Medium	Supported
placenta	decidual cells	High	Supported
placenta	trophoblastic cells	High	Supported
prostate	glandular cells	Low	Supported
rectum	glandular cells	Medium	Supported
salivary gland	glandular cells	Medium	Supported
seminal vesicle	glandular cells	Medium	Supported
skeletal muscle	myocytes	Medium	Supported
skin 1	cells in basal layer	Medium	Supported
skin 1	cells in spinous layer	Low	Supported
skin 1	endothelial cells	High	Supported
skin 1	fibrohistiocytic cells	High	Supported
skin 1	langerhans cells	Low	Supported
skin 1	lymphocytes	High	Supported
skin 1	melanocytes	Medium	Supported
skin 2	cells in basal layer	Medium	Supported
skin 2	cells in spinous layer	Low	Supported
skin 2	endothelial cells	High	Supported
skin 2	fibrohistiocytic cells	High	Supported
skin 2	lymphocytes	High	Supported
skin 2	melanocytes	Medium	Supported
small intestine	glandular cells	Medium	Supported
smooth muscle	smooth muscle cells	Low	Supported
soft tissue 1	chondrocytes	Medium	Supported
soft tissue 1	fibroblasts	Medium	Supported
soft tissue 1	peripheral nerve	Low	Supported
soft tissue 2	fibroblasts	Medium	Supported
soft tissue 2	peripheral nerve	Low	Supported
spleen	cells in red pulp	High	Supported
spleen	cells in white pulp	High	Supported
stomach 1	glandular cells	Medium	Supported
stomach 2	glandular cells	Medium	Supported
testis	Leydig cells	High	Supported
testis	sertoli cells	Medium	Supported
testis	spermatogonia cells	Medium	Supported
thyroid gland	glandular cells	Medium	Supported
tonsil	germinal center cells	High	Supported
tonsil	non-germinal center cells	High	Supported
tonsil	squamous epithelial cells	Medium	Supported
urinary bladder	urothelial cells	Medium	Supported
vagina	squamous epithelial cells	Low	Supported

Summary of Q9Y490

Gene: TLN1, KIAA1027, TLN
Protein: Talin-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q9Y490

Gene: TLN1, KIAA1027, TLN Protein: Talin-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: TLN1, KIAA1027, TLN
Protein: Talin-1