MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q9Y4G6

Gene: TLN2, KIAA0320
Protein: Talin-2

Protein family
Protein sequence
Protein function

Catalytic activity

The protein has not catalytic activity

Publications

Structure

GO term

GO ontology	GO term	GO description
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0007043	cell-cell junction assembly
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0005178	integrin binding
Molecular Function	GO:0005200	structural constituent of cytoskeleton
Molecular Function	GO:0005198	structural molecule activity
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0001726	ruffle
Cellular Component	GO:0045202	synapse

InterPro / Pfam

InterPro	InterPro name
IPR000299	FERM domain
IPR002558	I/LWEQ domain
IPR011993	PH-like domain superfamily
IPR014352	FERM/acyl-CoA-binding protein superfamily
IPR015009	Vinculin-binding site-containing domain
IPR015224	Talin, central
IPR019747	FERM conserved site
IPR019748	FERM central domain
IPR019749	Band 4.1 domain
IPR029071	Ubiquitin-like domain superfamily
IPR032425	Talin, N-terminal F0 domain
IPR035963	FERM superfamily, second domain
IPR035964	I/LWEQ domain superfamily
IPR036476	Talin, central domain superfamily
IPR036723	Alpha-catenin/vinculin-like superfamily
IPR037438	Talin-1/2, rod-segment

Pfam	Pfam name
PF00373	FERM central domain
PF01608	I/LWEQ domain
PF08913	Vinculin Binding Site
PF09141	Talin, middle domain
PF16511	N-terminal or F0 domain of Talin-head FERM

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Enhanced
caudate	neuronal cells	Medium	Enhanced
cerebellum	Purkinje cells - cytoplasm/membrane	Medium	Enhanced
cerebellum	molecular layer - neuropil	Low	Enhanced
cerebral cortex	neuronal cells	Medium	Enhanced
cerebral cortex	neuropil	Medium	Enhanced
heart muscle	cardiomyocytes	Medium	Enhanced
kidney	proximal tubules (microvilli)	Medium	Enhanced
lung	macrophages	Low	Enhanced
placenta	decidual cells	Low	Enhanced
rectum	glandular cells	Low	Enhanced
seminal vesicle	glandular cells	Low	Enhanced
testis	sertoli cells	Low	Enhanced
testis	spermatogonia cells	Medium	Enhanced
thyroid gland	glandular cells	Low	Enhanced
tonsil	non-germinal center cells	Low	Enhanced

Disease