MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.2.2.-	Hydrolases; Glycosylases; Hydrolysing N-glycosyl compounds;
3.5.1.-	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides;

PDB	Resolution (Å)	PDB name
2EEE		Solution structure of the A1pp domain from human protein C6orf130
2L8R		Solution structure of human protein C6orf130 in complex with ADP-ribose
2LGR		Solution structure of human protein C6orf130, a putative macro domain
4J5Q	1.35	TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1, apo structure
4J5R	1.25	TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1 bound to ADP-HPD
4J5S	1.55	TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1 ADP-ribose complex

GO ontology	GO term	GO description
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0140291	peptidyl-glutamate ADP-deribosylation
Biological Process	GO:0051725	protein de-ADP-ribosylation
Biological Process	GO:0042278	purine nucleoside metabolic process
Molecular Function	GO:0140293	ADP-ribosylglutamate hydrolase activity
Molecular Function	GO:0061463	O-acetyl-ADP-ribose deacetylase activity
Molecular Function	GO:0001883	purine nucleoside binding
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0090734	site of DNA damage

InterPro	InterPro name
IPR002589	Macro domain
IPR043472	Macro domain-like

Pfam	Pfam name
PF01661	Macro domain

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	Medium	Approved
bone marrow	hematopoietic cells	Low	Approved
breast	glandular cells	Low	Approved
breast	myoepithelial cells	Low	Approved
bronchus	respiratory epithelial cells	Low	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	Purkinje cells	Low	Approved
cerebellum	cells in granular layer	Medium	Approved
cerebellum	cells in molecular layer	Medium	Approved
cerebral cortex	neuronal cells	High	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Low	Approved
colon	peripheral nerve/ganglion	High	Approved
duodenum	glandular cells	High	Approved
epididymis	glandular cells	Low	Approved
fallopian tube	glandular cells	Low	Approved
hippocampus	neuronal cells	Low	Approved
kidney	cells in tubules	Low	Approved
liver	hepatocytes	Medium	Approved
lymph node	non-germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
ovary	follicle cells	High	Approved
pancreas	exocrine glandular cells	Low	Approved
prostate	glandular cells	Low	Approved
rectum	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Medium	Approved
skin 1	Langerhans	Low	Approved
skin 1	fibroblasts	Low	Approved
skin 2	epidermal cells	Low	Approved
small intestine	glandular cells	Medium	Approved
soft tissue 2	chondrocytes	High	Approved
soft tissue 2	fibroblasts	Low	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Low	Approved
testis	cells in seminiferous ducts	High	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	non-germinal center cells	Low	Approved