Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.1.3.16
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
protein-serine/threonine phosphatase
3.1.3.48
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
protein-tyrosine-phosphatase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1ZZW | 1.6 | Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5 |
| 2OUC | 2.2 | Crystal structure of the MAP kinase binding domain of MKP5 |
| 2OUD | 2.8 | Crystal structure of the catalytic domain of human MKP5 |
| 3TG1 | 2.71 | Crystal structure of p38alpha in complex with a MAPK docking partner |
| 6MC1 | 2.7 | Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor |
| 7U4O | 2.3 | Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor |
| 7U4R | 3.14 | Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor |
| 7UMU | 2.51 | Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor |
| 7UMV | 1.8 | Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydropyrido[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor |
| 7UN0 | 3.0 | Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-chloro-5,6-dihydrobenzo[h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor |
| 7UN4 | 2.7 | Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0016311 | dephosphorylation |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:0043508 | negative regulation of JUN kinase activity |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0010633 | negative regulation of epithelial cell migration |
| Biological Process | GO:0050680 | negative regulation of epithelial cell proliferation |
| Biological Process | GO:1905042 | negative regulation of epithelium regeneration |
| Biological Process | GO:0048715 | negative regulation of oligodendrocyte differentiation |
| Biological Process | GO:1903753 | negative regulation of p38MAPK cascade |
| Biological Process | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation |
| Biological Process | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response |
| Biological Process | GO:0048709 | oligodendrocyte differentiation |
| Biological Process | GO:0035970 | peptidyl-threonine dephosphorylation |
| Biological Process | GO:1990264 | peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
| Biological Process | GO:0045591 | positive regulation of regulatory T cell differentiation |
| Biological Process | GO:0002819 | regulation of adaptive immune response |
| Biological Process | GO:0090335 | regulation of brown fat cell differentiation |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0051403 | stress-activated MAPK cascade |
| Molecular Function | GO:0008432 | JUN kinase binding |
| Molecular Function | GO:0033549 | MAP kinase phosphatase activity |
| Molecular Function | GO:0033550 | MAP kinase tyrosine phosphatase activity |
| Molecular Function | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity |
| Molecular Function | GO:0048273 | mitogen-activated protein kinase p38 binding |
| Molecular Function | GO:0017018 | myosin phosphatase activity |
| Molecular Function | GO:0016791 | phosphatase activity |
| Molecular Function | GO:0008330 | protein tyrosine/threonine phosphatase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000340 | Dual specificity phosphatase, catalytic domain |
| IPR000387 | Tyrosine-specific protein phosphatases domain |
| IPR001763 | Rhodanese-like domain |
| IPR008343 | Mitogen-activated protein (MAP) kinase phosphatase |
| IPR016130 | Protein-tyrosine phosphatase, active site |
| IPR020422 | Dual specificity protein phosphatase domain |
| IPR029021 | Protein-tyrosine phosphatase-like |
| IPR036873 | Rhodanese-like domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00581 | Rhodanese-like domain |
| PF00782 | Dual specificity phosphatase, catalytic domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-112409 | RAF-independent MAPK1/3 activation | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-5675221 | Negative regulation of MAPK pathway | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-9652817 | Signaling by MAPK mutants | Leaf | R-HSA-1643685 | Disease |